配体-金属电荷转移促进的电光催化烷烃氧化官能团化研究进展OA

The direct functionalization of unactivated aliphatic C(sp3)-H bonds under mild conditions continues to pose a formidable chal-lenge,primarily due to their high bond dissociation energies and inherent nonpolar characteristics.This endeavor stands as a pivotal research avenue within the realm of modern synthetic chemistry.The synergistic approach that integrates ligand-to-metal charge transfer(LMCT)-fa-cilitated hydrogen atom transfer(HAT)with electrochemical techniques has opened up a novel pathway for achieving C(sp3)-H bond func-tionalization under such mild conditions.This review offers a comprehensive and systematic overview of the most recent advancements in iron-based and cerium-based catalytic systems,specifically tailored for electrophotocatalytic C(sp3)-H bond functionalization,with a focus on the design principles,catalytic mechanisms and application characteristics of the two systems in reactions including borylation,alkenylation,C-H alkylation of heteroarenes and tandem cyclization,as well as a comparison of the advantages and limitations of different systems.This review aims to clarify the core logic of LMCT-electrophotocatalytic synergistic activation of alkane C(sp3)-H bonds,dissect their reaction mechanisms and application potential,summarize the existing challenges and future development directions,and provide reference for subsequent research in this field.