敏感肌适用的微油珠精华液的制备及功效评价OA
Preparation and efficacy evaluation of a micro-oil bead serum suitable for sensitive skin
将油相加入水相搅拌分散成均匀微油珠,制备出敏感肌适用的紧致抗皱精华液.通过测定不同黏度的精华液中油珠粒径随增稠剂含量变化曲线,研究了黏度对油珠大小的影响.通过人皮肤成纤维细胞(HSF)增殖实验和细胞毒性检测,评价精华液的紧致抗皱功效和安全性.结果表明,黏度在1 500～2 000 mPa·s时油珠粒径在450～550 μm,具有良好外观;精华液在2.50%、1.25%、0.625%、0.312 5%、0.156 25%、0.078 125%、0.039 062 5%和0.019 531 25%含量下无细胞毒性且对人皮肤成纤维细胞具有显著促进增殖作用.该微油珠精华液工艺简易,安全无刺激,具有良好的紧致抗皱功效.
A firming and anti-wrinkle serum suitable for sensitive skin was prepared by dispersing the oil phase into the aqueous phase under stirring to form uniform micro-oil beads.The effect of viscosity on oil bead size was investigated by examining the relationship between thickener concentration and oil bead diameter in serums with different viscosities.The firming and anti-wrinkle efficacy and safety of the serum were evaluated through human skin fibroblast(HSF)proliferation and cytotoxicity assays.The results showed that when the viscosity ranged from 1 500 to 2 000 mPa·s,the oil bead diameter ranged from 450 to 550 μm,providing an aesthetically pleasing appearance.The serum exhibited no cytotoxicity at concentrations of 2.50%,1.25%,0.625%,0.312 5%,0.156 25%,0.078 125%,0.039 062 5%,and 0.019 531 25%,and significantly promoted the proliferation of HSF cells.These findings indicate that the micro-oil bead serum can be prepared using a simple process and possesses favorable safety,non-irritating properties,and effective firming and anti-wrinkle efficacy.
齐艳芳;彭晏;植洁婷;章次宏
宇肽生物(东莞)有限公司深圳分公司,广东 深圳 518000深圳市维琪科技股份有限公司,广东 深圳 518000宇肽生物(东莞)有限公司深圳分公司,广东 深圳 518000宇肽生物(东莞)有限公司,广东 东莞 523000
化学化工
化妆品敏感肌紧致抗皱细胞实验
cosmeticssensitive skinfirming and anti-wrinklecell assay
《日用化学品科学》 2026 (8)
20-25,6
评论