自由基介导非活化烯烃的氢-二氯甲基化反应OA

This study reports a hydrogen-dichloromethylation reaction of non-activated olefins mediated by radicals in the absence of metal catalysts and synthesizes a series of dichloromethyl substituted alcohol compounds with moderate to high yields.This reaction,using tert-butyl hydroperoxide(TBHP)as radical initiator and hydrogen source and chloroform as dichloromethyl source,has the advantages of wide substrate applicability,mild reaction conditions,and simple experimental operation.It provides an effective way to construct structurally diverse dichloromethyl substituted derivatives under mild conditions.