慢性乙型肝炎功能性治愈的多维度诊断标志物OA

Chronic hepatitis B(CHB)is a significant public health issue worldwide.The persistent presence of covalently closed circular DNA of the hepatitis B virus(HBV)and the integration of the viral genome are the main obstacles limiting the achievement of virological cure in CHB.Functional cure has now become an important goal in antiviral therapy for CHB,and its accurate determination and efficacy prediction rely on a comprehensive assessment of multidimensional diagnostic markers.This article systematically reviews the research advances in diagnostic markers associated with functional cure in CHB,focusing on the clinical value of serological and virological indicators(HBsAg quantification and HBV DNA),genomic,transcriptomic,proteomic,and metabolomic markers,and indicators associated with host innate immunity and adaptive immunity.Furthermore,it discusses future research directions such as the establishment of unified detection standards and the construction of predictive models combining multiple markers,in order to promote the precise assessment and individualized management of functional cure in CHB.