基于两样本孟德尔随机化探讨原发性头痛与失眠的因果关联研究OA

Objective To investigate the bidirectional causal relationship between primary head-ache disorders and insomnia using Mendelian randomization(MR)analysis.Methods A bidirec-tional two-sample MR analysis was performed using summary statistics from genome-wide association studies(GWAS).The inverse-variance weighted(IVW)method was used as the primary analysis,supplemented by MR-Egger regression,weighted median,simple mode,and weighted mode methods.Heterogeneity was assessed using Cochran's Q test.Pleiotropy was evaluated using the MR-Egger in-tercept and MR-PRESSO methods.The stability of the results was assessed using leave-one-out analy-sis.Results Forward MR analysis indicated that other headache syndromes significantly increased the risk of insomnia(OR=1.078,95％CI:1.053 to 1.104,P＜0.001,PFDR＜0.001).Reverse MR analysis demonstrated that insomnia significantly increased the risk of other headache syndromes(OR=2.179,95％CI:1.448 to 3.279,P＜0.001,PFDR=0.002)and showed a potential positive as-sociation with trigeminal neuralgia(OR=2.888,95％CI:1.104 to 7.558,P=0.031,PFDR=0.177).Sensitivity analyses confirmed the robustness of the forward causal estimates.In the reverse analysis,although heterogeneity and potential pleiotropy were observed for the association between insomnia and other headache syndromes,the results remained robust after MR-PRESSO correction.Conclusion This study confirms a robust bidirectional causal association between other headache syndrome and insom-nia,suggesting that insomnia may be a potential risk factor for trigeminal neuralgia.