基于中医"肺热叶焦,则生痿躄"理论探讨慢阻肺与肌骨共病交互机制OA

Chronic obstructive pulmonary disease(COPD)is a lung disease characterized by high rates of morbidity,disability,and mortality,often accompanied by musculoskeletal diseases such as sarcopenia and osteoporosis(OP).Although the pathogeneses underlying COPD and musculoskeletal comorbidities are not yet fully unveiled,recent studies suggest that pulmonary,muscle,and bone factors communicate through cross-organ signaling,constituting a"lung-musculoskeletal interaction"mechanism that plays a key role in the onset and progression of these comorbidities.The theory of"scorched lung causing atrophy and flaccidity"from the Inner Canon of Huangdi provides a theoretical basis for the pathological relationship between the lung and musculoskeletal system diseases.This paper combines this theory with modern biomedical mechanisms to explore the interrelationship between COPD and musculoskeletal comorbidities,further elucidating the role of the"lung-musculoskeletal interaction"mechanism in the development of these comorbidities.