基于自噬及氧化应激探讨"益肾通络法"的微观机制及在糖尿病肾病中的作用OA

The basic pathogenesis of diabetic kidney disease(DKD)is identified as"kidney deficiency and collateral obstruction"in traditional Chinese medicine,based on which the primary method for its treatment features"enhancing the kidney and promoting kidney collaterals",but the underlying microscopic mechanisms of the method still remain unclear.Oxidative stress injury caused by imbalance between pro-oxidant and antioxidant is one of the important pathogeneses of DKD,and autophagy pathway activation is the key to effectively resist oxidative stress injury of renal intrinsic cells.The"kidney-enhancing and collateral-promoting method"can activate the autophagy pathway,and then remove the excessive accumulation of pro-oxidation substances in the intrinsic cells of DKD kidneys,thus restoring the balance of oxidation/antioxidation and resisting the oxidative stress damage of cells.On the basis of previous research,it is proposed that activating the autophagy pathway to counteract oxidative stress damage is the micro-mechanism of the"kidney-enhancing and collateral-promoting method"for treating DKD,and that elucidating its intrinsic mechanism will provide a theoretical basis for the treatment of DKD in traditional Chinese medicine,inheriting the essence and innovating with integrity.