基质金属蛋白酶-9、PR结构域蛋白2表达与脑胶质瘤患者临床特征及预后的关系OA

Objective To explore the expression of matrix metalloproteinase-9(MMP-9)and PR domain protein 2(PRDM2)in glioma and its relationship with the clinical characteristics and prognosis of patients.Methods A total of 125 patients diagnosed with glioma and undergoing surgery in Dongxiang District People's Hospital,Fuzhou City,Jiangxi Province and the First Affiliated Hospital of Nanchang University from January 2019 to March 2022 were selected as research objects.The glioma tissues of the patients during the operation were collected as the observation group,and the adjacent tissues were collected as the control group.The patients were divided into the survival group and the death group according to the death situation 3 years after the operation.The expression of MMP-9 and PRDM2 were detected by immunohistochemistry,and the related influencing factors were screened by multivariate Cox regression analysis.Results The results of univariate analysis indicated that there were statistically significant differences in the expressions of MMP-9 and PRDM2 in glioma tissues between the observation group and the control group(P＜0.05).There were statistically sig-nificant differences in pathological grade and tissue differentiation between patients with low expression of MMP-9 and those with high expression of MMP-9(P＜0.05).There were statistically significant differences in pathological grade and tissue differentiation between patients with low expression of PRDM2 and those with high expression of PRDM2(P＜0.05).The results of the survival curve analysis suggest that the survival rates of the MMP-9 high-expression group and the PRDM2 high-expression group were 26.92％(21/78)and 32.98％(31/94),respectively,which were lower than those of the MMP-9 low-expression group and the PRDM2 low-expression group,which were 65.96％(31/47)and 70.97％(22/31),respectively(P＜0.05).The results of mul-tivariate analysis indicated that pathological grade,MMP-9,PRDM2 were risk factors for death in patients with glioma(P＜0.05).Conclusion The high expression of MMP-9 and PRDM2 is related to the tumor pathological grade and tissue differ-entiation of glioma patients,and it is also an important factor affecting the death of patients.