疏风散寒方治疗慢性阻塞性肺疾病急性加重期疗效及相关机制探讨OA
Preliminary study on the efficacy and related mechanisms of Shufeng Sanhan Formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease
目的 观察疏风散寒方治疗慢性阻塞性肺疾病急性加重期(AECOPD)的效果,初步分析其作用机制.方法 将 96 例 AECOPD 患者按照随机数字表法分为 2 组,每组 48 例,对照组予标准化西医治疗,观察组在对照组治疗基础上予疏风散寒方口服.2 组均治疗10 d.比较2 组治疗前后中医证候评分、第1s 用力呼气容积(FEV1)、FEV1 占预计值百分比(FEV1%)、FEV1 占用力肺活量(FVC)百分比(FEV1/FVC)、动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、血氧饱和度(SaO2)及血清锌指蛋白 36(ZFP36)、炎症发生区因子 2(FIZZ2)水平,并统计临床疗效.结果 观察组临床疗效优于对照组(P<0.05).2 组治疗后各项中医证候评分均较本组治疗前降低(P<0.05),且观察组治疗后咳嗽、咯痰、喘息、鼻塞评分均低于对照组(P<0.05).2 组治疗后 FEV1、FEV1%、FEV1/FVC 均较本组治疗前升高(P<0.05),且观察组治疗后均高于对照组(P<0.05).2 组治疗后 PaO2、SaO2 均较本组治疗前升高(P<0.05),PaCO2 均降低(P<0.05),且观察组治疗后 PaO2、SaO2 均高于对照组(P<0.05),PaCO2 低于对照组(P<0.05).2 组治疗后血清 ZFP36 水平均升高(P<0.05),FIZZ2 水平均降低(P<0.05),且观察组治疗后血清 ZFP36 水平高于对照组(P<0.05),FIZZ2 水平低于对照组(P<0.05).结论 疏风散寒方可有效缓解风寒袭肺型 AECOPD 患者症状,改善肺功能和血气指标,提高临床疗效,其机制可能与调节 ZFP36、FIZZ2 表达有关.
Objective To observe the therapeutic effect of Shufeng Sanhan Formula in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and to preliminarily explore its mechanism of action.Methods A total of 96 patients with AECOPD were randomly assigned,using the random number table method,to two groups,with 48 cases in each group.The control group received standardized Western medical treatment,while the observation group received oral Shufeng Sanhan Formula in addition to the treatment given to the control group.Both groups were treated for 10 days.Before and after treatment,the two groups were compared in terms of traditional Chinese medicine syndrome scores,forced expiratory volume in 1 second(FEV1),FEV1 as a percentage of predicted value(FEV1%),FEV1/forced vital capacity(FVC),arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SaO2),and serum levels of zinc finger protein 36(ZFP36)and found in inflammatory zone 2(FIZZ2).Clinical efficacy was also assessed.Results The clinical efficacy of the observation group was superior to that of the control group(P<0.05).After treatment,all traditional Chinese medicine syndrome scores decreased in both groups compared with before treatment(P<0.05),and the scores for cough,sputum production,wheezing,and nasal congestion in the observation group were lower than those in the control group(P<0.05).After treatment,FEV1,FEV1%,and FEV1/FVC increased in both groups compared with before treatment(P<0.05),and the post-treatment values in the observation group were higher than those in the control group(P<0.05).After treatment,PaO2 and SaO2 increased in both groups,whereas PaCO2 decreased(P<0.05);compared with the control group,the observation group had higher PaO2 and SaO2 and lower PaCO2 after treatment(P<0.05).After treatment,serum ZFP36 levels increased in both groups(P<0.05),while FIZZ2 levels decreased(P<0.05);compared with the control group,the observation group had higher serum ZFP36 levels and lower FIZZ2 levels after treatment(P<0.05).Conclusion Shufeng Sanhan Formula can effectively relieve symptoms in patients with AECOPD of the wind-cold invading the lung type,improve lung function and blood gas parameters,and enhance clinical efficacy.Its mechanism may be related to the regulation of ZFP36 and FIZZ2 expression.
沈珊;吴安源;朱希成;庄玲伶
安徽省合肥市第八人民医院中医科,安徽 合肥 238000安徽省合肥市第八人民医院中医科,安徽 合肥 238000安徽省合肥市第八人民医院中医科,安徽 合肥 238000吉林省中医药科学院(吉林省中医药科学院第一临床医院)儿科,吉林 长春 130100
医药卫生
慢性阻塞性肺疾病急性加重中药疗法
Acute exacerbation of chronic obstructive pulmonary diseaseTraditional Chinese medicine therapy
《河北中医》 2026 (8)
1258-1262,1267,6
国家中医药管理局2022年中医药古籍文献和特色技术传承专项项目(编号:GZY-KJS-2022-030)
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