基于T淋巴细胞亚群、肿瘤标志物及不良反应探究扶元复衡汤对中晚期非小细胞肺癌患者化疗的增效减毒作用OA

Objective To investigate the synergistic efficacy and toxicity-reducing effects of Fuyuan Fuheng Decoction in chemotherapy for patients with advanced and locally advanced non-small cell lung cancer(NSCLC),based on T-lymphocyte subsets,tumor markers,and adverse reactions.Methods A total of 112 patients with advanced and locally advanced NSCLC were divided into two groups according to treatment regimen,with 56 cases in each group.The control group received platinum-based chemotherapy,while the study group received Fuyuan Fuheng Decoction in addition to the treatment given to the control group.Both groups were treated for 3 chemotherapy cycles.Short-term efficacy,tumor markers(squamous cell carcinoma antigen[SCC],neuron-specific enolase[NSE],carbohydrate antigen 125[CA125],cytokeratin 19 fragment[CYFRA21-1]),T-lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),prognosis-related indicators(β2-microglobulin[β2-MG],red blood cell distribution width[RDW],D-dimer[D-D]),traditional Chinese medicine(TCM)syndrome scores,Karnofsky performance status(KPS),Functional Assessment of Cancer Therapy-Lung(FACT-L)scores,and adverse reactions were compared between the two groups.Results The short-term efficacy in the study group was superior to that in the control group(82.14%[46/56]vs 62.50%[35/56],P<0.05).After 1 and 3 chemotherapy cycles,serum SCC,NSE,CA125,and CYFRA21-1 levels decreased in both groups compared with baseline(P<0.05),and the levels in the study group were lower than those in the control group at the same time points(P<0.05).After 1 and 3 chemotherapy cycles,peripheral blood CD3+,CD4+,and CD4+/CD8+levels decreased in both groups compared with baseline(P<0.05),while these indices were higher in the study group than in the control group at the same time points(P<0.05).After 1 and 3 chemotherapy cycles,serum β2-MG,RDW,and D-D levels decreased in both groups compared with baseline(P<0.05),and were lower in the study group than in the control group at the same time points(P<0.05).After 1 and 3 chemotherapy cycles,TCM syndrome scores decreased in both groups compared with baseline(P<0.05),whereas KPS and FACT-L scores increased(P<0.05).The study group had lower TCM syndrome scores and higher KPS and FACT-L scores than the control group at the same time points(P<0.05).The incidences of gastrointestinal reactions,myelosuppression,and fatigue were lower in the study group than in the control group(P<0.05).Conclusion Fuyuan Fuheng Decoction can alleviate the impact of chemotherapy on T-lymphocyte subsets in patients with NSCLC and further reduce serum tumor marker levels,thereby lowering the risk of adverse reactions and exerting synergistic efficacy and toxicity-reducing effects.