慢传输型便秘的诊疗进展OA

As a prevalent gastrointestinal disorder,slow transit constipation(STC)has demonstrated a steadily increasing incidence in recent years.The precise etiology and underlying pathological mechanisms of STC remain incompletely elucidated,with conservative management often proving inadequate for achieving complete symptom resolution in a subset of patients.Chronic disease progression significantly compromises patients'quality of life,and prolonged ineffective treatment may predispose individuals to serious complications including gastrointestinal neoplasms and cardiovascular disorders,thereby imposing substantial economic and psychological burdens.Within this clinical context,surgical intervention has emerged as a viable therapeutic alternative for refractory STC.The majority of surgical candidates typically present with a multi-year history of constipation refractory to conventional therapies such as oral laxatives,rectal stimulants,and enema administration.Current standard surgical approaches predominantly involve total or subtotal colectomy.Notably,subtotal colectomy with cecosigmoid anastomosis has demonstrated particularly favorable outcomes in recent clinical practice,while the Jinling procedure,a novel surgical technique specifically designed for mixed-type constipation,has shown distinctive therapeutic advantages.This comprehensive review systematically evaluates contemporary literature to provide an integrated perspective on STC,encompassing its etiological factors,pathogenic mechanisms,diagnostic modalities,current treatment paradigms,and surgical outcomes.Through this scholarly synthesis,we aim to deepen the clinical understanding of this condition and propose innovative theoretical frameworks to inform future therapeutic strategies.