T3、FER与HDL对子宫肌瘤生长的影响及预测价值OA

Objective To investigate the associations of triiodothyronine(T3),ferritin(FER),and high-density lipoprotein cholesterol(HDL-C)with the maximum diameter of uterine fibroids(UF)and to evaluate their predictive value for the risk of fibroid growth.Methods A total of 114 patients with UF who were hospitalized at the Uygur Medicine Hospital of Xinjiang Uygur Autonomous Region between January 1 and December 31,2023,were retrospectively enrolled.Thirty-four clinical variables were collected.According to the maximum fibroid diameter,patients were divided into a small-diameter group(<2.5 cm,n=68)and a large-diameter group(≥2.5 cm,n=46).Spearman's rank correlation analysis was performed to identify clinical indicators associated with fibroid diameter.Differences between groups were compared using the independent-samples t test or the Mann-Whitney U test,as appropriate.Variables with statistically significant differences were subsequently included in a binary Logistic regression model to identify independent influencing factors.Receiver operating characteristic(ROC)curves were constructed to evaluate their predictive performance.Results Spearman's rank correlation analysis showed that the maximum diameter of UF was positively correlated with age(r=0.241,P=0.010)and T3(r=0.190,P=0.043),but negatively correlated with FER(r=-0.304,P=0.001)and HDL-C(r=-0.322,P=0.001).Compared with the small-diameter group,the large-diameter group had significantly higher age(Z=-2.737,P=0.006),T3(t=-2.169,P=0.032),and free triiodothyronine(FT3)(t=-2.116,P=0.037),whereas FER(Z=-2.022,P=0.043)and HDL-C(Z=-3.163,P=0.002)were significantly lower.Binary Logistic regression analysis identified age(OR=1.084,95%CI:1.002-1.173),FER(OR=0.974,95%CI:0.950-0.999),and HDL-C(OR=0.167,95%CI:0.033-0.845)as independent influencing factors for a maximum fibroid diameter≥2.5 cm(all P<0.05).ROC curve analysis demonstrated that HDL-C had the best predictive performance(AUC=0.820,95%CI:0.737-0.903),followed by age(AUC=0.781,95%CI:0.698-0.864)and FER(AUC=0.703,95%CI:0.603-0.803),with all P=0.001.Conclusion Age,ferritin,and high-density lipoprotein cholesterol showed moderate predictive performance for the risk of uterine fibroid growth and may provide useful clinical references for the risk assessment of UF.