Heterogeneous viral-host response at single-cell resolution and viral adaptive mutational atlas in birds and mammals upon H5 influenza virus infectionOA
Heterogeneous viral-host response at single-cell resolution and viral adaptive mutational atlas in birds and mammals upon H5 influenza virus infection
Jiahao Zhang;Ruixuan Zhu;Zhengze Wang;Qian Zhang;Jinjun Liu;Xiaona Chen;He Zhang;Xinyu Zhuang;Xiaoshu Zhou;Hui Guo;Tao Zhang;Huaiyuan Cai;Yi Liu;Junlong Xiong;Jiangtao Zhou;Weize Xu;Xiaofeng Wu;Weixin Jia;Zhangyong Ning;Ke Xiao;Jinxia Dai;Weifeng Shi;Tingting Man;Wenbao Qi;Gang Cao;Ming Liao;Lihong Huang;Letian Li;Yu Chen;Haixing Yang;Shiping Ding;Yiqun Chen
Key Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||State Key Laboratory for Animal Disease Control and Prevention,South China Agricultural University,Guangzhou 510642,China||State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China||National Avian Influenza Para-Reference Laboratory,Guangzhou 510642,China||National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control,Guangzhou 510642,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaLingang Laboratory,Shanghai Tech University,Shanghai 200031,ChinaCollege of Bioinformatics,Huazhong Agricultural University,Wuhan 430070,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,ChinaChangchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Changchun 130122,China||State Key Laboratory of Pathogen and Biosecurity,Key Laboratory of Jilin Province for Zoonosis Prevention and Control,Changchun 130122,ChinaChangchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Changchun 130122,China||State Key Laboratory of Pathogen and Biosecurity,Key Laboratory of Jilin Province for Zoonosis Prevention and Control,Changchun 130122,ChinaCollege of Biomedicine and Health,Huazhong Agricultural University,Wuhan 430070,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||State Key Laboratory for Animal Disease Control and Prevention,South China Agricultural University,Guangzhou 510642,China||National Avian Influenza Para-Reference Laboratory,Guangzhou 510642,China||National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control,Guangzhou 510642,China||Key Laboratory of Zoonoses Prevention and Control of Guangdong Province,Guangzhou 510642,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||State Key Laboratory for Animal Disease Control and Prevention,South China Agricultural University,Guangzhou 510642,ChinaShenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518107,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaRuijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China||Shanghai Institute of Virology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||State Key Laboratory for Animal Disease Control and Prevention,South China Agricultural University,Guangzhou 510642,China||National Avian Influenza Para-Reference Laboratory,Guangzhou 510642,China||National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control,Guangzhou 510642,China||Key Laboratory of Zoonoses Prevention and Control of Guangdong Province,Guangzhou 510642,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China||Faculty of Life and Health Sciences,Shenzhen University of Advanced Technology,Shenzhen 518107,China||Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518107,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||National Avian Influenza Para-Reference Laboratory,Guangzhou 510642,China||National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control,Guangzhou 510642,China||Key Laboratory of Zoonoses Prevention and Control of Guangdong Province,Guangzhou 510642,China||College of Animal Science and Technology,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,China||Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases,Ministry of Agriculture and Rural Affairs,Institute of Animal Health,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||State Key Laboratory for Animal Disease Control and Prevention,South China Agricultural University,Guangzhou 510642,China||National Avian Influenza Para-Reference Laboratory,Guangzhou 510642,China||National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control,Guangzhou 510642,ChinaChangchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Changchun 130122,China||State Key Laboratory of Pathogen and Biosecurity,Key Laboratory of Jilin Province for Zoonosis Prevention and Control,Changchun 130122,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070,ChinaState Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China||College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,ChinaKey Laboratory of Zoonoses,Ministry of Agriculture and Rural Affairs,College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China
H5 subtypehighly pathogenic avian influenza virusscRNA-seqlung microenvironmentcross-speciesadaptive mutationsMiP-seq
H5 subtypehighly pathogenic avian influenza virusscRNA-seqlung microenvironmentcross-speciesadaptive mutationsMiP-seq
《国家科学评论（英文版）》 2026 (14)
65-83,19
This work was supported by the National Natural Science Foundation of China(32330104,32302956,and 32461120064,to W.Q.,J.Z.,and M.L.),the Special Funds Project for Strategic Emerging Industries of Shenzhen Municipal De-velopment and Reform Commission(https://fgw.sz.gov.cn/)(XMHT20240215002,to G.C.),Guangdong Basic and Applied Basic Research Foundation(2026B1515020044,to J.Z.),and the Research of Cross-Scale,High-Throughput Spatial Multi-OmicsTechnologies and Development of Breaktrough Patho-logical Diagnostics Products(XMHT20240215002,to G.C.).
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