菊苣水提物对雏鸡生长性能及部分免疫、肝肾和肠道功能的影响OA

This study aimed to investigate the effects of Cichorium intybus L.aqueous extract on the growth performance,immunity,liver and kidney function,and intestinal function of 6-day-old chickens,with flor-fenicol as the control,providing new options for the practice of reducing and substituting antibiotics in tra-ditional Chinese veterinary medicine.The chickens were randomly divided into a blank control group(A),a florfenicol group(B),and low(C),medium(D),and high(E)dose groups of Cichorium intybus L.aque-ous extract.The test lasted for 6 days,during which serum,immune organs,liver,kidney,and intestinal tis-sue samples were collected to detect relevant indicators.The results showed that at 6 days of age,compared with the control group,the florfenicol group exhibited significantly higher feed conversion ratio(F/G),hepatorenal index,serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),uric acid,u-rea nitrogen,creatinine,liver tumor necrosis factor-α(TNF-α),and malondialdehyde(MDA)levels(P＜0.05),while average daily gain(ADG),average daily feed intake(ADFI),bursa of Fabricius index,serum immunoglobulin G(IgG)and immunoglobulin M(IgM)levels,jejunal villus height(VH),villus height to crypt depth ratio(V/C),and lipase activity were significantly reduced(P＜0.05).In the low-dose group,ADG,serum IgG,jejunal V/C,and amylase activity were significantly increased(P＜0.05).In the medium-dose group,ADG,ADFI,thymus index,serum immunoglobulin A(IgA)and IgG levels,jejunal V/C,amyl-ase activity,and chymotrypsin activity were significantly increased(P＜0.05).Liver MDA levels were sig-nificantly reduced in the low-and medium-dose groups(P＜0.05).Jejunal amylase activity was significantly increased in the high-dose group(P＜0.05).These results indicated that substituting Cichorium intybus L.aqueous extract for florfenicol in the drinking water of chickens can increase growth performance,enhance immune function,maintain hepatorenal health,and improve intestinal function,with the 2.5 g/L dose showing the best effect.