肌肉骨骼疼痛共性核心集与中医外治特色集双维结局指标集的构建OA

Objective To develop a core outcome set for musculoskeletal pain(MKP-COS)and a specific out-come set for traditional Chinese medicine external treatment(MKP-SOS-ETCM),providing a standardized basis for clinical research in musculoskeletal pain and serving as a reference for core outcome set(COS)development in related fields.Methods Existing COS studies on musculoskeletal pain(MKP)were systematically searched,and core out-come indicators were extracted to form an initial item pool.The Delphi method was used,in which experts were invited to reach consensus on MKP-COS and MKP-SOS-ETCM.The inclusion criteria for consensus are set as an importance score of 7-9 points with ≥75％of experts reaching agreement.Results A total of 47 COS studies were included,and after discussion and consolidation,a preliminary item pool containing 34 outcome indicators was established.After three rounds of Delphi expert consensus,MKP-COS was identified,including five outcomes including pain,motor function,joint range of motion,activities of daily living,and adverse events/adverse reactions;MKP-SOS-ETCM included six outcomes involving stiffness(including morning stiffness),joint tenderness count,work status/productivity,overall physician assessment,structural damage,and muscle strength.Conclusion This study has established MKP-COS and MKP-SOS-ETCM,forming a dual-dimensional outcome assessment system integrating both disease commonality and intervention specificity.