基于穴位敏化探讨针刺得气的科学内涵与外延OA

Acupoint sensitization and deqi(得气)are key factors influencing the therapeutic efficacy of acupunc-ture.Acupoint sensitization serves as an important prerequisite for achieving deqi.Based on a review of recent research progress on acupoint sensitization and deqi,this study proposes that the biological basis of deqi primarily encompasses the biomechanical basis of mechanotransduction and microenvironmental changes,the energy metabolic basis of molecular events and signaling pathway activation,the neurophysiological basis of receptor activation and central inte-gration,and the biological effect basis of bidirectional regulation within the neuro-endocrine-immune network.The extension of deqi refers to a sustained and relatively stable biological homeostasis after deqi through self-regulation and remodeling of the organism,which mainly manifests as neural reflex threshold resetting and neural functional remodeling,re-establishment of endocrine homeostasis,rebalancing of immune homeostasis,and temporal changes in gene expres-sion.Systematic investigation into the scientific connotation and extension of deqi not only contributes to a deeper elu-cidation of the mechanisms underlying acupuncture's therapeutic actions,but also provides theoretical foundations and practical guidance for the optimization of clinical therapeutic regimens.