中医药数字人:中药整合药理学2.0的创新引擎OA

As the primary carrier of clinical treatment in traditional Chinese medicine(TCM),TCM formulae require elucidation of the interaction laws between their chemical substance basis and biological activities,which represents a key scientific issue in TCM re-search.The"TCM integrative pharmacology"theory previously proposed by our team has become an important paradigm in modern TCM research.However,current studies still face several limitations,including a static analytical perspective,insufficient spatiotem-poral information,and unclear mechanisms of cross-organ coordinated regulation.Based on these challenges,this paper further propo-ses the innovative concept of a"TCM digital human".Guided by the integrative pharmacology research paradigm,and drawing on ad-vanced technologies such as virtual cells and virtual physiological human systems,this framework integrates artificial intelligence and multiscale modeling approaches to construct a computable virtual life system with TCM characteristics,ranging from virtual cells and virtual organs to a digital human.This system provides key support for the digital representation of TCM theory and for the scientific elucidation of the mechanisms underlying the therapeutic effects of TCM formulae.