中药活性成分纳米递送系统治疗肾脏疾病的研究进展OA
Research progress in nano-delivery systems of active ingredients in TCM for treating kidney diseases
肾脏疾病发病率逐年攀升,已成为全球性公共卫生问题.现代医学治疗存在诸多局限,传统中医药对于肾病的治疗也无法避免生物利用度低、靶向性弱等问题.纳米药物递送系统(NDDS)凭借纳米颗粒的独特理化特性,可通过被动与主动靶向递送策略,实现中药活性成分精准的肾脏疾病治疗.该文系统阐述了 NDDS 的定义、分类、理化影响因素以及核心优势,重点总结其在不同肾脏疾病中的应用和机制,探讨其临床转化面临的挑战与未来前景,旨在为肾病中医药精准治疗开辟新路径.
Kidney diseases,with rising incidences,pose a serious challenge to global public health.Modern medical treatments exhibit numerous limitations,while TCM approaches for kidney diseases face low bioavailability and insufficient targeting.The unique physicochemical properties of nanoparticles enable nanoparticle drug delivery systems(NDDS)to achieve precise targeting of TCM active ingredients for kidney diseases through passive and active targeting strategies.This paper systematically describes the definition,classification,physicochemical factors,and core advantages of NDDS.Furthermore,it summarizes the applications and mechanisms of NDDS in various kidney diseases and discusses the challenges and future prospects for clinical translation.This review aims to establish a novel path for the precision treatment of kidney diseases with TCM.
陈正;陈至;卢志强;谭红艳;陈金莲;胡淑娟;彭亚军
湖南中医药大学,湖南 长沙 410208甘肃中医药大学,甘肃 兰州 730000湖南中医药大学,湖南 长沙 410208湖南中医药大学,湖南 长沙 410208湖南中医药大学,湖南 长沙 410208湖南中医药大学,湖南 长沙 410208湖南中医药大学第一附属医院,湖南 长沙 410007
纳米递送系统中药活性成分肾脏疾病靶向递送
nano-delivery systemsactive ingredients of TCMkidney diseasestargeted delivery
《中国中药杂志》 2026 (15)
4257-4267,11
湖南省自然科学基金项目(2023JJ30473)湖南省卫生健康科研课题(20256869,20257025)
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