基于"因加而发"探析特发性肺纤维化急性加重病机与防治OA

Acute exacerbation of idiopathic pulmonary fibrosis(AE-IPF)is a major cause of mortality among IPF patients.The theory of'disease with latent pathogen induced by a new pathogen'originates from the Huangdi Neijing,emphasizes that the disease exacerbation occurs when latent pathogenic factors within the body are triggered by new pathogenic influences.Building upon the theory of'disease with latent pathogen induced by a new pathogen',this article explores the pathogenesis and prevention and treatment of AE-IPF.The'latent pathogen'refers to the pre-existing condition of'lung deficiency with stasis in the collaterals' formed during the stable phase of IPF;the'new pathogen'refers to the new pathogenic factors that stir the latent pathogens.Ultimately,the combination of these old and new pathogenic factors creates a pattern of'lung heat with stasis in the collaterals',thereby triggering AE-IPF.In terms of treatment,prior to the onset of the disease,one should'strengthen the root and eliminate the cause,whilst carefully avoiding external pathogenic factors';during the acute exacerbation phase,one should'treat the manifestation and eliminate the addition,providing emergency care and preventing deterioration';and during the recovery phase,one should'combine clearing and nourishing,supporting the vital qi and ensuring a favorable outcome'.This provides new insights and a theoretical basis for the prevention and treatment of AE-IPF.