钩藤生物碱治疗神经系统疾病的研究进展OA

Nervous system diseases have complex pathogen-esis,and the existing therapeutic drugs have not yet met clini-cal needs.Uncaria rhynchophylla is sweet in taste and cool in nature,with the effects of calming endogenous wind to stop con-vulsions,clearing heat and pacifying the liver.Modern pharma-cological studies have shown that Uncaria rhynchophylla con-tains various active ingredients such as rhynchophylline and iso-rhynchophylline,which can exert neuroprotective effects through multiple targets and pathways.The specific mecha-nisms include regulating calcium ion homeostasis,alleviating oxidative stress,inhibiting neuroinflammation,regulating neu-rotransmitters,protecting the blood-brain barrier,and inhibit-ing neuronal apoptosis.Uncaria alkaloids have obvious advan-tages and potential in the treatment of various nervous system diseases.This article systematically reviews the mechanisms underlying the preventive and therapeutic effects of uncaria al-kaloids on different neurological diseases,aiming to provide a theoretical basis and research directions for the application of uncaria in neurological disorders and the development of related innovative drugs.