抗乌头类生物碱所致快速性心律失常的作用机制研究进展OA

Aconitum species are commonly used in traditional Chinese medicine(TCM)clinical practice.Their main active and toxic components,diester diterpenoid alkaloids(DDAs),can induce tachyarrhythmias(TA),which may become life-threatening in severe cases.In recent years,the frequent occur-rence of poisoning incidents caused by improper dosage,formu-lation,or processing has emerged as a major public health con-cern.Currently,targeted therapeutic agents for DDAs induced TA are still lacking in clinical practice,and conventional symp-tomatic treatments often lead to significant adverse effects.Therefore,there is an urgent need to explore safe and effective novel adjuvant therapeutic strategies.TCM offers extensive ex-perience in the prevention and treatment of aconite poisoning.On the one hand,various herbal monomers can exert synergistic therapeutic effects through multi-target mechanisms within dis-ease networks;on the other hand,processing methods can structurally modify DDAs to achieve targeted detoxification.This article systematically reviews recent advances in the mechanisms by which herbal monomers counteract DDAs in-duced TA,aiming to provide a theoretical basis for the develop-ment and clinical translation of novel detoxification strategies.