血清25(OH)D3、Leptin对早产儿视网膜病变的预测价值OA

Objective To discuss the predictive value of serum 25 hydroxyvitamin D3[25(OH)D3]and Leptin for retinopathy of prematurity(ROP)in premature infants.Methods 80 cases of ROP in our hospital(ROP group)were selected and divided into severe and mild groups according to the severity of the disease,and 80 cases of healthy preterm infants in the same period(control group)were selected.Logistic analysis,relative risk analysis,ROC curve analysis and Bootstrap internal validation were used.Results The serum 25(OH)D3 level in ROP group was lower than that in control group,and the serum Leptin level was higher(P＜0.05).The serum 25(OH)D3 level in severe group was lower than that in mild group,and the serum Leptin level was higher(P＜0.05).Leptin was a risk factor for ROP(P＜0.05),and 25(OH)D3 was a protective factor(P＜0.05).The risk of ROP in children with low level 25(OH)D3 and high level Leptin was 1.680 times and 1.585 times higher than that in children with high level 25(OH)D3 and low level Leptin.The combined prediction of serum 25(OH)D3 and Leptin for the occurrence of ROP is superior to the prediction alone(Z=2.503,2.518,P＜0.05).The calibration curve for predicting ROP was close to the ideal curve(H-L test was x2=7.754,P=0.654).Conclusion The expression of serum 25(OH)D3 in children with ROP is decreased,and the expression of Leptin is increased,which is related to the severity of the disease.The combined detec-tion has better predictive value for ROP in children.