Sirt1/PGC-1α信号通路在睡眠障碍发病机制中的研究进展OA

Sleep disorders have emerged as a significant global public health issue,with their prevalence increasing annually.The underlying mechanisms remain complex and incompletely understood,involving multiple pathways such as oxidative stress,inflammatory responses,neurotransmitter imbalances,and neuroendocrine dysregulation.Sirt1/PGC-1α signaling plays a pivotal role in cellular metabolism,oxidative stress regulation,and mitochondrial function,and is implicated in sleep disorder pathogenesis.As a class Ⅲ histone deacetylase,Sirt1 activates antioxidant enzymes and suppresses the activity of inflammation-related transcription factors through deacetylation;acting as a transcriptional coactivator,PGC-1α regulates mitochondrial biogenesis and enhances mitochondrial antioxidant capacity.Their interaction jointly regulates oxidative stress,inflammatory responses,mitochondrial function,and neurotransmitter activity,improving pathological sleep disorder manifestations.Although research on the Sirt1/PGC-1α pathway has made progress,the specific mechanisms in different brain regions and cell types involved require further investigation.Optimizing drug development targeting this pathway is essential to provide stronger evidence for the precision treatment of sleep disorders.