DHA和EPA在脂肪组织中缓解胰岛素抵抗的作用机制研究进展OA

Insulin resistance contributes substantially to the pathogenesis of metabolic diseases including obesity,and impaired adipose tissue function is pivotal for the onset of insulin resistance.In recent years,docosahexaenoic acid(DHA)and eicosapentaenoic acid(EPA),the main components of n-3 polyunsaturated fatty acids,have received extensive attention for their effects in alleviating insulin resistance.Numerous studies have shown that DHA and EPA can regulate adipose tissue.This article provides a comprehensive review of the mechanisms by which DHA and EPA alleviate insulin resistance in adipose tissue,focusing on anti-inflammatory effects,lipid metabolism regulation,diabetic pathways,and gut microbiota interactions.The findings offer theoretical foundations for further investigation into the molecular mechanisms involved in insulin resistance mitigation by these compounds,establishing a theoretical basis for developing drugs targeting metabolic diseases using n-3 polyunsaturated fatty acids.