抗血管生成靶向药物致药物性高血压的影响因素OA
Analysis of influencing factors for drug-induced hypertension induced by antiangiogenesis targeted drugs
目的 分析抗血管生成靶向药物(ATD)引发药物性高血压的影响因素.方法 采用前瞻性研究设计,纳入于2023年12月至2024年8月在医院就诊并使用ATD的非高血压患者964例,收集其性别、年龄、肿瘤类别、ATD类别、饮食情况、活动情况、焦虑抑郁水平、行为类型等信息.通过每周2次血压随访,依据《中国高血压防治指南(2024年修订版)》中的高血压诊断标准,有291例患者发生了药物性高血压,将其作为高血压组;其余673例未发生药物性高血压者作为无高血压组.结果 二元logistic回归分析显示,性别、职业、身体质量指数(BMI)、饮食口味、活动情况、睡眠状况、焦虑抑郁水平、ATD类别和肿瘤类型是ATD引发药物性高血压的危险因素.其中男性、高BMI、较少活动、存在睡眠障碍、存在焦虑状态、使用贝伐珠单抗者、典型A型性格者及罹患消化系统肿瘤者更容易发生ATD相关药物性高血压;而个体职业、退休和未就业者以及抑郁水平较高者相对更不容易发生药物性高血压.结论 ATD所致药物性高血压的发生受多因素影响,提示在用药过程中应对重点人群开展用药前筛查风险并优先干预可调节因素,用药期间不仅要严密监测患者血压,还需关注其心理状况,结合其用药特征和疾病特征,为患者构建个性化、有针对性的血压管理方案,保障患者用药安全.
AIM To analyze the influencing factors of drug-induced hypertension induced by anti-angiogenesis targeted drugs(ATD).METHODS Using a prospective study design,964 non-hypertensive patients treated with ATD in a hospital from December 2023 to August 2024 were enrolled.Patients' gender,age,tumor type,ATD type,diet,activity,anxiety and depression levels,and behavior types were collected.Through the follow-up of blood pressure twice a week,according to the diagnostic criteria of hypertension in the Chinese Guidelines for the Prevention and Treatment of Hypertension(2024 Revision),291 patients with drug-induced hypertension were selected as the hypertension group,and the remaining 673 patients without drug-induced hypertension were selected as the non-hypertension group.RESULTS Binary logistic regression analysis showed that gender,occupation,body mass index(BMI),diet taste,activity,sleep status,physical anxiety and depression levels,ATD category,and tumor type were the risk factors for ATD-induced hypertension.Males,individuals with a high BMI,those who were less physically active,those with sleep disorders,those experiencing anxiety,bevacizumab users,individuals with a type A personality,and patients diagnosed with digestive system tumors were more prone to ATD-related drug-induced hypertension.Conversely,self-employed individuals,retirees,unemployed individuals,and those experiencing higher levels of depression were less likely to develop drug-induced hypertension.CONCLUSION The occurrence of ATD-induced drug-related hypertension is influenced by multiple factors,suggesting that key populations should undergo pre-medication risk screening and prioritized intervention for modifiable factors during treatment.Throughout the medication process,it is essential not only to closely monitor patients' blood pressure but also to pay attention to their psychological status.By integrating patients' medication and disease characteristics,personalized and targeted blood pressure management plans should be developed to ensure medication safety.
龚航;陆箴琦;吴洪斌;李雅群;杨瑒;王伟英;许晨
复旦大学附属肿瘤医院护理部,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032复旦大学附属肿瘤医院护理部,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032复旦大学附属肿瘤医院药剂科,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032复旦大学附属肿瘤医院药剂科,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032复旦大学附属肿瘤医院护理部,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032复旦大学附属肿瘤医院护理部,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032复旦大学附属肿瘤医院护理部,上海 200032||复旦大学上海医学院肿瘤学系,上海 200032
医药卫生
抗血管生成靶向药物药物性高血压危险因素用药安全不良反应
anti-angiogenesis targeted drugdrug-induced hypertensionrisk factormedication safetyadverse reaction
《中国临床药学杂志》 2026 (6)
531-537,7
2024年上海市护理学会科研课题(编号2024MS-B04)
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