加味葛根芩连汤联合布拉氏酵母菌散治疗小儿轮状病毒性肠炎的临床疗效OA
Clinical Efficacy of Modified Gegen Qinlian Decoction Combined with Saccharomyces Boulardii Sachets in Treatment of Infantile Rotavirus Enteritis
目的:探讨加味葛根芩连汤联合布拉氏酵母菌散治疗小儿轮状病毒性肠炎的临床疗效.方法:以2023年1月至2026年1月我院收治的80例轮状病毒性肠炎患儿为研究对象,随机分为对照组和观察组,对照组(40例)予以常规西医治疗及布拉氏酵母菌散口服,观察组(40例)在对照组治疗基础上予以加味葛根芩连汤内服.比较2组临床治疗总有效率、症状消失时间,治疗前后中医证候积分、炎症指标、肠道菌群变化,以及不良反应发生率.结果:观察组治疗总有效率(95.00%)明显高于对照组(80.00%),P<0.05.观察组退热时间、呕吐消失时间、腹泻停止时间、脱水纠正时间及轮状病毒转阴时间均短于对照组(P<0.05或P<0.001).治疗后,2组中医证候积分、白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均较治疗前降低,且观察组降幅更大(P<0.001);治疗后,观察组乳酸杆菌、双歧杆菌水平高于对照组,大肠埃希菌水平低于对照组(P<0.001).对照组与观察组不良反应发生率分别为7.50%和10.00%,组间比较差异无统计学意义,P>0.05.结论:加味葛根芩连汤联合布拉氏酵母菌散可提升小儿轮状病毒性肠炎临床疗效,加快症状消退与病毒转阴,减轻炎症反应,调节肠道菌群,且安全可靠.
Objective To explore the clinical efficacy of modified Gegen Qinlian Decoction combined with Saccharomyces boulardii sachets for infantile rotavirus enteritis.Methods A total of 80 children diagnosed with rotavirus enteritis admitted to our hospital from January 2023 to January 2026 were selected as research subjects and randomly divided into a control group and an observation group,with 40 cases in each group.The control group received routine Western medicine treatment and oral Saccharomyces boulardii sachets,while the observation group was additionally given oral modified Gegen Qinlian Decoction on the basis of the therapeutic regimen of the control group.The two groups were compared in terms of total clinical effective rate,disappear-ance time of symptoms,traditional Chinese medicine(TCM)syndrome scores before and after treatment,inflammatory indicators,changes in intestinal flora,and incidence of adverse reactions.Results The total clinical effective rate of the observation group was 95.00%,which was significantly higher than 80.00%of the control group(P<0.05).The time for fever relief,vomiting disappearance,diarrhea cessation,dehydration correction and rotavirus turning negative in the observation group were all shorter than those in the control group(P<0.05 or P<0.001).After treatment,TCM syndrome scores,white blood cell count(WBC),C-reactive protein(CRP)and interleukin-6(IL-6)in both groups decreased compared with those before treatment,and the reduction range in the observation group was more prominent(P<0.001).After treatment,the levels of Lactobacillus and Bifidobacterium in the observation group were higher,while the level of Escherichia coli was lower than those in the control group(P<0.05).The incidences of adverse reactions in the control group and the observation group were 7.50%and 10.00%respectively,with no statistically significant difference between the two groups(P>0.05).Conclusion Modified Gegen Qinlian Decoction combined with Saccha-romyces boulardii sachets can improve the clinical efficacy of infantile rotavirus enteritis,accelerate symptom resolution and viral clearance,alleviate inflammatory reactions and regulate intestinal flora,with reliable safety profile.
邹锦;张义敬
驻马店市中医院 儿童保健康复科(河南 驻马店 463000)驻马店市中医院 儿科(河南 驻马店 463000)
加味葛根芩连汤布拉氏酵母菌散轮状病毒性肠炎小儿疗效
Modified Gegen Qinlian DecoctionSaccharomyces boulardii sachetsRotavirus enteritisChildrenClinical efficacy
《中国肛肠病杂志》 2026 (8)
43-46,4
评论