大分割放疗与常规分割放疗在直肠癌患者中的应用效果对比分析OA
Comparative Analysis of Clinical Efficacy of Hypofractionated Radiotherapy and Conventional Fractionated Radiotherapy in Patients with Rectal Cancer
目的:对比术前大分割放疗与常规分割放疗在直肠癌患者中的应用效果.方法:选取2023年1月至2024年12月我院收治的80例直肠癌患者为研究对象,根据随机数字表法分为对照组和研究组,每组40例,2组均拟接受手术治疗,术前对照组行常规分割放疗,研究组行大分割放疗.比较2组放疗临床疗效、围术期相关指标,以及术后临床症状改善情况、生存质量及不良反应发生情况.结果:研究组放疗后客观缓解率为 50.00%,疾病控制率为 95.00%,明显高于对照组(27.50%,77.50%),均P<0.05.研究组术前治疗总费用[(1.98±0.26)万元]明显少于对照组[(2.97±0.41)万元](P<0.05).研究组术后便血(1.03±0.25分)、便频(1.26±0.32分)、疼痛(1.32±0.22分)方面症状评分均低于对照组(1.54±0.32分、1.51±0.22分、1.71±0.22分),均 P<0.001.研究组术后生理(71.58±6.54分)、心理(60.11±6.28分)、社会关系(51.91±3.69分)、环境领域(50.11±3.65分)生存质量评分均高于对照组(65.14±5.44分、55.84±6.21分、49.21±2.68分、46.21±2.48分),P<0.05或P<0.001.研究组不良反应发生率(32.50%)低于对照组(75.00%),P<0.001.结论:相较于常规分割放疗,大分割放疗在直肠癌患者术前的应用效果更好,可更有效地改善患者临床症状,提高患者生存质量,降低不良反应发生率,且治疗费用低,值得临床推广应用.
Objective To compare the clinical efficacy of preoperative hypofractionated radiotherapy and conventional fractionated radiotherapy in patients with rectal cancer.Methods A total of 80 patients with rectal cancer admitted to our hospital from January 2023 to December 2024 were enrolled as research subjects.The patients were divided into a control group and a study group by random number table method,with 40 cases in each group.All patients were scheduled for surgical treatment.The control group received conven-tional fractionated radiotherapy before operation,while the study group received hypofractionated radiotherapy.The clinical efficacy of radiotherapy,perioperative indicators,postoperative improvement of clinical symptoms,quality of life and incidence of adverse reactions were compared between the two groups.Results The objec-tive response rate and disease control rate after radiotherapy in the study group were 50.00%and 95.00%,which were significantly higher than those in the control group(27.50%and 77.50%)(all P<0.05).The total preoperative treatment cost of the study group[(19.8±2.6)thousand yuan]was markedly lower than that of the control group[(29.7±4.1)thousand yuan](P<0.05).The postoperative symptom scores of hematochezia(1.03±0.25),frequent defecation(1.26±0.32)and pain(1.32±0.22)in the study group were all lower than those in the control group(1.54±0.32,1.51±0.22,1.71±0.22)(all P<0.001).The postoperative quality of life scores in physical domain(71.58±6.54),psychological domain(60.11±6.28),social relationships domain(51.91±3.69)and environmental domain(50.11±3.65)of the study group were higher than those of the control group(65.14±5.44,55.84±6.21,49.21±2.68,46.21±2.48)(all P<0.05 or P<0.001).The incidence of adverse reactions in the study group(32.50%)was lower than that in the control group(75.00%)(P<0.001).Conclusion Compared with conventional fractionated radio-therapy,preoperative hypofractionated radiotherapy achieves superior clinical outcomes in patients with rectal cancer.It can more effectively relieve clinical symptoms,improve patients'quality of life,reduce the incidence of adverse reactions and cut down treatment costs,which is worthy of clinical promotion and application.
胡静;袁一木;祁峰;侯良学
商丘市第一人民医院 放射治疗部(河南 商丘 476000)商丘市第一人民医院 放射治疗部(河南 商丘 476000)商丘市第一人民医院 放射治疗部(河南 商丘 476000)商丘市第一人民医院 肿瘤放疗一科(河南 商丘 476000)
大分割放疗常规分割放疗直肠癌疗效
Hypofractionated radiotherapyConventional fractionated radiotherapyRectal cancerClinical efficacy
《中国肛肠病杂志》 2026 (8)
26-29,4
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