Innovative strategies for anti-fibrotic drugs discovery from traditional Chinese medicineOA

作者：Guang Xin;Zhaotong Cong;Wen Huang;Tao Wang;Qilong Zhou;Sanyin Zhang;Zeliang Wei;Ke Li;Wei Chen;Dan Sun;Shilin Chen

作者单位：Institute of Integrated Traditional Chinese and Western Medicine,Natural and Biomimetic Medicine Research Center,Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province,West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,ChinaInstitute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaInstitute of Integrated Traditional Chinese and Western Medicine,Natural and Biomimetic Medicine Research Center,Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province,West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,ChinaInstitute of Integrated Traditional Chinese and Western Medicine,Natural and Biomimetic Medicine Research Center,Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province,West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,ChinaInstitute of Integrated Traditional Chinese and Western Medicine,Natural and Biomimetic Medicine Research Center,Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province,West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,ChinaInstitute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaInstitute of Integrated Traditional Chinese and Western Medicine,Natural and Biomimetic Medicine Research Center,Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province,West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,ChinaInstitute of Integrated Traditional Chinese and Western Medicine,Natural and Biomimetic Medicine Research Center,Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province,West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,ChinaInstitute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaInstitute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaInstitute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China

中文关键词：biosynthesisclassical formulacross-scale validationdrug discoveryfibrotic diseasesoptimizationtissue-orientedtraditional Chinese medicine

英文关键词：biosynthesisclassical formulacross-scale validationdrug discoveryfibrotic diseasesoptimizationtissue-orientedtraditional Chinese medicine

刊名：《中草药（英文版）》 2026 (3)

页码/页数：499-514,16

基金：This work was supported by Natural Science Foundation of Sichuan Province(No.2025ZNSFSC00512025ZNSFSC05842025ZNSFSC07002025ZNSFSC09382024NSFSC07132025NSFJQ0032)and the Innovative Chinese Medicine Preclinical Research Fund of"Liqing No.2",West China Hospital,Sichuan University(No.161200012).

DOI：10.1016/j.chmed.2025.10.005