Fe3O4/ZnO@ZnS/Cu2S复合材料协同利福平高抗菌活性OA

Bleeding and bacterial infection are critical factors influencing wound healing,and antibiotics play a significant role in their management.Rifampicin(RIF),a macrocyclic antibiotic,is commonly employed in the first-line treatment of infected wounds.However,the rapid rise in cases of multidrug-resistant bacteria(MDR)globally has led to a gradual decline in the medicinal efficacy of rifampicin,resulting in substantial economic losses.Consequently,it is essential to enhance the therapeutic value of traditional antibiotics and to develop bacteriostatic agents with highly effective antibacterial properties for wound treatment.In this study,Fe3O4/ZnO@ZnS/Cu2S@RIF nanocomposites were synthesized,utilizing Fe3O4/ZnO as the core and ZnS as the shell,with RIF loaded onto the surface.The antibacterial efficacy against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and drug-resistant Salmonella(T-Salmonella)was evaluated.The results indicated that the composite material exhibited exceptional antibacterial activity,achieving an inhibition rate of 99.99％against all three bacterial strains at a concentration of 100 μg/mL within 40 min.This composite effectively compromised the integrity of the bacterial cell wall,altered cell membrane permeability,and induced bacterial apoptosis.Furthermore,in vivo experiments demonstrated that the composite material achieved a wound healing rate of(80±0.9)％by the ninth day post-infection,indicating a significant reparative effect.These findings provide a theoretical foundation and experimental support for the clinical application of advanced wound dressings.