ZCF4-dependent suppression of MMP-9 drives virulence in fluconazole-resistant Candida aurisOA
ZCF4-dependent suppression of MMP-9 drives virulence in fluconazole-resistant Candida auris
Yue-Mei Hong;Wan-Xing Xu;Yan-Yan Sun;Tian-Yi Zhang;Jian Guo;Jian Bing;Guang-Hua Huang;Wen-Juan Wu;Lei Pan;Chang-Bin Chen;Hui Wang;Lu Wang;Ning-Ning Liu;Zuo-Jing Yin;Yun Zou;Zhi-Wen Wang;Xiu-Li Wang;Di Wu;Xiang-Kang Zeng;Jin-An Zhou
State Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaDepartment of Laboratory Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai,ChinaState Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan University,Shanghai,ChinaState Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan University,Shanghai,ChinaDepartment of Laboratory Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai,ChinaThe Joint Laboratory for Biomedical Research and Pharmaceutical Innovation,Unit of Pathogenic Fungal Infection & Host Immunity,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,ChinaThe Joint Laboratory for Biomedical Research and Pharmaceutical Innovation,Unit of Pathogenic Fungal Infection & Host Immunity,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaThe Joint Laboratory for Biomedical Research and Pharmaceutical Innovation,Unit of Pathogenic Fungal Infection & Host Immunity,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,ChinaThe Joint Laboratory for Biomedical Research and Pharmaceutical Innovation,Unit of Pathogenic Fungal Infection & Host Immunity,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,ChinaThe Joint Laboratory for Biomedical Research and Pharmaceutical Innovation,Unit of Pathogenic Fungal Infection & Host Immunity,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,ChinaState Key Laboratory of Systems Medicine for Cancer,Center for Single-Cell Omics,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Candida aurisfluconazole resistancezincvirulencefungal infection
Candida aurisfluconazole resistancezincvirulencefungal infection
《微生物与宿主健康（英文）》 2026 (7)
439-456,18
We acknowledge funding from the MOST Key R&D Program of China(grant number 2024YFC2309600 to J.A.Z.),the Natural Science Foundation of China(grant numbers 32422004 and 32270202 to N.N.L.),the Medicine and Engineering Interdisci-plinary Research Fund of Shanghai Jiao Tong University(grant number 24X010301328 to N.N.L.),Program of Shanghai Aca-demic Research Leader(grant number 23XD1422300 to N.N.L.),the Computational Biology Program of Science and Technology Commission of Shanghai Municipality(STCSM)(grant number 25JS2810200 to N.N.L.),and Innovative Research Team of High-level Local Universities in Shanghai(to N.N.L.).We thank Dr.Hai-Long Li and Professor Chen Ding from China Medical University for providing strains.We also want to thank all of the lab members in the Liu Lab at Shanghai Jiao Tong University School of Medicine for their help in the discussion and preparation of the manuscript.
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