活体肾移植受者术后早期感染的临床特征及危险因素OA

Objective To analyze the clinical features and risk factors of early postoperative infection in living kidney trans-plant recipients,and to provide basis for the prevention and control of perioperative infection.Methods A retrospective study was con-ducted on the baseline information and clinical data of the patients who underwent living kidney transplantation in Beijing Friendship Hospital Affiliated to Capital Medical University from January 2019 to October 2024.Univariate analysis and exploratory multivariate logistic regression analysis were used to identify risk factors of early postoperative infection.Results A total of 119 living kidney trans-plant recipients were included,among whom 22 received preoperative treatment with plasma exchange,rituximab,and/or eculizumab.Early postoperative infection occurred in 24 cases(20.17%),with urinary tract infection being the most common type(18/24,75.00%).The predominant pathogens identified were enterococcus and enterobacter.Univariate analysis showed that the operation time was an influencing factor for early postoperative infection(OR=1.010,95%CI:1.002-1.018,P<0.05).Exploratory multivari-ate logistic regression analysis revealed that the operation time(OR=1.013,95%CI:1.003-1.023,P<0.05),diabetes mellitus(OR=19.040,95%CI:1.640-221.010,P<0.05),and methylprednisolone dose during induction immunotherapy(OR=1.172,95%CI:1.023-1.342,P<0.05)were related to early postoperative infection.Conclusions There is an infection risk after living kidney transplantation.Longer operation time,pre-existing diabetes mellitus,and a higher methylprednisolone dose during induction immunotherapy are associated with an increased risk of early postoperative infection.