中国中老年人衰弱发展轨迹与童年不良经历的关联:基于10年随访数据的纵向研究OA

Objective:To examine the association between adverse childhood experiences(ACEs)and the 10-year frailty development trajectories in Chinese middle-aged and older adults,so as to provide evidence for life-course-oriented healthy ageing promotion strategies.Methods:Using data from the China Health and Retirement Longitudinal Study(CHARLS)spanning 2011-2020,we identified frailty development trajectories through group-based trajectory modelling,and applied multinomial Logistic regression to analyse the relationship between ACEs and these trajectories.Results:A total of 10 032 middle-aged and older adults were included.The baseline frailty index was 0.14±0.09,and 78.86%of the respondents reported at least one ACE.Three frailty trajectories were identified in the Chinese sample:stable non-frailty(65.9%),critical turning point(23.9%),and progressive frailty(10.1%).Multinomial Logistic regression showed that ACEs were significantly associated with frailty trajectories(P<0.05),and a higher number of ACEs was associated with a higher relative risk of belonging to more severe frailty trajectory groups(P<0.05).Conclusions:ACEs are associated with the 10-year frailty development trajectories in Chinese middle-aged and older adults,suggesting that childhood adversity may be an important distal risk factor for the long-term evolution of frailty in later life.This highlights the need for early prevention from a life-course perspective and precise intervention in old age.