复方中草药对感染呼吸道疫病的肉牛生长性能、血清免疫及生化指标的影响OA

The experiment aimed to investigate the effects of a self-formulated compound Chinese herbal medicine on the growth performance,serum immune,and biochemical indicators of beef cattle naturally infected with respiratory diseases.A total of 40 beef cattle clinically diagnosed with respiratory diseases were randomly divided into a Chinese herbal formula group(administered with the compound decoction)and a flunixin meglumine+cephalosporin group(administered via intramuscular injection).Another 20 healthy beef cattle were selected as the control group.Each group had five replicates with four cattle per replicate.The total experimental period lasted 12 days,including a 5-day treatment period and a 7-day recovery period.The results showed that the cure rate in the Chinese herbal formula group was higher than that in the flunixin meglumine+cephalosporin group.Compared with the flunixin meglumine+cephalosporin group,the total weight gain and average daily gain in the Chinese herbal formula group were significantly increased(P＜0.05),and the feed-to-gain ratio was significantly decreased(P＜0.05).The serum concentrations of immunoglobulin A(IgA),immunoglobulin M(IgM),and interferon-γ(IFN-γ)in the Chinese herbal formula group were significantly increased(P＜0.05),while the concentrations of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were significantly decreased(P＜0.05).The activities of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and concentrations of creatinine(CREA),total cholesterol(TC),triglyceride(TG),and non-esterified fatty acids(NEFA)in serum in the Chinese herbal formula group were significantly lower than those in the flunixin meglumine+cephalosporin group(P＜0.05).The study shows that this compound Chinese herbal medicine has significant therapeutic effects on bovine respiratory diseases.It can improve the growth performance,enhance immunity,alleviate inflammatory responses,protect liver and kidney functions,and regulate lipid metabolism,with overall efficacy superior to that of flunixin meglumine+cephalosporin.