挥发性有机化合物分析与食管癌诊断的研究现状及进展OA

Esophageal carcinoma is one of the major gastrointestinal malignancies threatening human health.Its early symptoms are atypical,and around 70%of patients are diagnosed at the middle and advanced stages,with a 5-year survival rate of less than 30%.Although traditional endoscopic biopsy is the gold standard,it has limitations such as high invasive-ness,low compliance and difficulty in repeated monitoring.In recent years,detection of volatile organic compounds(VOCs),featuring non-invasiveness,convenience and the ability to reflect tumor metabolic status in real time,has provided new ideas for early screening and efficacy evaluation of esophageal cancer.This review summarizes the diagnostic bottlenecks of esophageal malignancies and the latest advances in VOCs detection technologies for exhaled breath and body fluids.It also systematically elaborates on the research status and future prospects of VOCs application in esophageal cancer,so as to provide a reference for relevant research and development.