基于风毒探讨糖尿病肾脏病病机演变及治疗策略OA

Diabetic kidney disease(DKD),categorized as"kidney consumption"or"Xiaoke kidney disease"in traditional Chinese medicine,is primarily characterized by proteinuria and progressive renal impairment.Controlling severe proteinuria remains a major therapeutic challenge,often leading to relentless functional decline."Wind-toxin"serves as a crucial pathological product in the evolu-tion of DKD's pathogenesis,persisting throughout the course of the disease and exhibiting the characteristics of both"wind"pathogens(mobility and rapid change)and"toxin"pathogens(virulence and tenacious stagnation).In the early stage,internal heat is exuberant while wind-toxin remains latent;in the intermediate stage,various pathogens transform into wind,and wind-toxin runs rampant;in the late stage,turbid toxins are generated internally,and wind-toxin lingers persistently.Based on the dynamic evolutionary patterns of wind-toxin pathogenesis,this paper proposes a stage-specific treatment strategy:in the early stage,expel pathogens to prevent disease progression and intercept the illness at its onset;in the intermediate stage,utilize insect-based and vine-type medicinal agents to search out wind and unblock the collaterals;and in the late stage,resolve and disperse wind-toxin and turbid toxins while harmonizing the internal organs.This study systematically elucidates a theoretical framework for managing DKD from the wind-toxin perspective,thereby providing a novel strategy for pattern differentiation and treatment in clinical practice.