原发性皮肤黏液癌1例OA

We report a case of primary cutaneous mucinous carcinoma.A 74-year-old male was diagnosed with a small lesion located on the lower eyelid of his right eye three years ago.The lesion had progressively enlarged over the past six months.Dermatological examination showed a purple lesion on the lower eyelid of the right eye,approximately 4 cm × 3 cm,characterized by a clear boundary,a soft texture and dilated capillaries.Further ultrasonography suggested a potential malignant transformation with a cystic-solid lesion.Immunohistochemistry(IHC)confirmed the primary skin mucinous carcinoma with CK7(+),CK20(-),CDX2(-),TTF-1(-),MSH2(+),MSH6(+),MLH1(+),PMS2(+),HER2(0),GATA-3(+).Subsequently,the sur-gical intervention involved local enlarged excision of the lesion in the lower right eyelid with pedi-cle muscle flap transfer,as well as peripheral nerve entrapment release and repair of the facial de-fect under general anesthesia.IHC examinations confirmed that the primary skin mucinous carci-noma showed no capsule invasion,vascular,or neural infiltration.Immunohistochemistry demon-strated CK7(+),ER(+,strong,positive rate 90％),PR(+,strong,positive rate 80％),AR(+,strong,positive rate 90％),Ki-67(+,approximately 15％),P53(weak+,approxi-mately 40％),GCDFP15(partially+),GATA-3(+),Villin(-),CK20(-).The patient is still under follow-up.