手足湿疹样表现的蕈样肉芽肿1例并文献复习OA

Objective To investigate the clinical features,diagnostic clues,and management of mycosis fungoides(MF)presenting with palmoplantar eczema-like lesions.Methods A retro-spective analysis of the clinical data of a patient with MF initially misdiagnosed as palmoplantar ec-zema was conducted.Diagnosis was confirmed by histopathology from multiple sites,immunohisto-chemistry,and T-cell receptor(TCR)gene rearrangement analysis.Results The patient had a 4-year history of refractory palmoplantar lesions and had failed multiple systemic therapies.Re-peated biopsies confirmed MF.Treatment with methotrexate,combined with local radiotherapy and phototherapy,resulted in marked improvement in erythema,infiltration,and scaling.Conclusions MF should be considered if a patient has chronic palmoplantar eczema-like lesions that are per-sistent or treatment-resistant.Immunophenotyping and TCR clonality analysis of the repeated biop-sies are necessary for accurate diagnosis and timely treatment.