强脉冲光联合化学换肤对轻中度痤疮患者皮肤表观生理参数的影响OA
Effects of intense pulsed light combined with chemical peeling on skin surface physiological parameters in patients with mild to moderate acne
目的 探讨强脉冲光联合化学换肤对轻中度痤疮患者皮肤表观生理参数的影响.方法 选取2024年1月—2025年6月应急总医院皮肤科门诊就诊的120例轻中度痤疮患者,随机分为A组、B组和C组,每组各40例.A组采用强脉冲光治疗,B组采用化学换肤治疗,C组采用强脉冲光联合化学换肤进行治疗,疗程均3个月,治疗间隔为每月1次,比较三组临床治疗效果、不良反应发生率及皮肤表观生理参数.结果 A组和B组治疗有效率均为97.50％,C组为100％,三组治疗有效率比较,差异无统计学意义(P=0.600).三组患者表层色素面积、毛孔数量、卟啉数量及皮肤平滑度在治疗前比较,差异均无统计学意义(F值分别为0.22、0.05、0.16、0.17,P值分别为0.804、0.952、0.856、0.847),而治疗后差异均有统计学意义(F值分别为8.92、3.48、25.44、28.38,P值分别为P＜0.001、0.034、P＜0.001、P＜0.001).进一步两两比较显示,C组治疗后表层色素面积低于A组和B组(t值分别为3.69、3.62,均P＜0.001),毛孔数量低于A组和B组(t值分别为2.28、2.29,P值分别为0.025、0.024),卟啉数量低于A组和B组(t值分别为6.52、5.76,均P＜0.001),皮肤平滑度高于A组和B组(t值分别为-6.09、-6.89,均P＜0.001).三组不良反应发生率比较,差异无统计学意义(P=0.857).结论 强脉冲光联合化学换肤能有效改善轻中度痤疮患者肤色、减少毛孔数量、降低卟啉荧光强度,效果显著.
Objective To investigate the effects of intense pulsed light(IPL)combined with chemical peeling on skin surface physiological parameters in patients with mild to moderate acne.Methods One hundred and twenty patients with mild to moderate acne who visited the Depart-ment of Dermatology at Emergency General Hospital from January 2024 to June 2025 were enrolled in this study.The cohort was randomly divided into three groups(40 patients per group):Group A received IPL only;Group B received chemical peeling only;and Group C received both IPL and chemical peeling.The treatment course lasted three months,with monthly intervals.The clinical efficacy,incidence of adverse reactions,and skin surface physiological parameters were compared among three groups.Results Group C achieved 100％effectiveness,while Group A and Group B were both 97.50％.However,there were no statistically significant differences in treatment effec-tiveness among the three groups(P=0.600).Before treatment,there were no significant differ-ences in surface pigment area,pore count,porphyrin count,or skin smoothness among the three groups of patients(F=0.22,0.05,0.16,0.17;P=0.804,0.952,0.856,0.847,respective-ly).After treatment,there were significant differences in surface pigment area,pore count,por-phyrin count,and skin smoothness among the three groups(F=8.92,3.48,25.44,28.38,re-spectively;P＜0.001,P=0.034,P＜0.001,P＜0.001,respectively).Further pairwise com-parisons showed that the surface pigment area in Group C was lower than that in Group A and Group B(t=3.69,3.62,respectively,both P＜0.001),the pore count in Group C was lower than that in Group A and Group B(t=2.28,2.29,respectively;P=0.025 and 0.024),the porphyrin count in Group C was lower than that in Group A and Group B(t=6.52 and 5.76,both P＜0.001),and the skin smoothness in Group C was higher than that in Group A and Group B(t=-6.09,-6.89,respectively,both P＜0.001).There was no significant difference in the incidence of adverse reactions among the three groups(P=0.857).Conclusions Intense pulsed light combined with chemical peeling can effectively improve the skin color of patients with mild to moderate acne,reduce the number of pores and porphyrin fluorescence intensity,and the effect is significant.
柴永丽;廉琛;刘爱英;朱晓如;刘晴云;伍艺佩
应急总医院,北京 100028应急总医院,北京 100028应急总医院,北京 100028应急总医院,北京 100028应急总医院,北京 100028应急总医院,北京 100028
痤疮强脉冲光化学换肤毛孔数量卟啉
acneintense pulsed lightchemical peelingpore countporphyrin
《皮肤性病诊疗学杂志》 2026 (7)
505-511,7
应急总医院学科科技创新基金项目(KX202401)
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