呼和浩特地区复发性口腔溃疡患者血清铁蛋白,维生素B12以及叶酸缺乏分析OA
Analysis of serum ferritin,vitamin B12 and folic acid deficiencies in patients with recurrent oral ulcer in Ho-hhot
目的:探讨内蒙古呼和浩特地区复发性口腔溃疡(ROU)患者血清铁蛋白、维生素 B12 及叶酸水平的分布特征及其与疾病发生的关系.方法:选取 2024 年 7 月～2025 年 7 月就诊于内蒙古医科大学附属医院的轻型ROU 患者 60 例作为 ROU 组,同期纳入健康体检者 60 例作为对照组.检测两组血清铁蛋白、维生素 B12、叶酸水平及相关血液学指标,并收集人口学特征、生活习惯及家族史等资料.采用 Logistic 回归分析 ROU 发生的独立危险因素.结果:ROU 组血清铁蛋白、维生素 B12 及叶酸水平均低于对照组(P<0.05).ROU 组血清铁蛋白、维生素 B12、叶酸缺乏率均高于对照组(P<0.05).ROU 组高度工作压力、喜辛辣饮食、不按时规律进餐、每周体育锻炼<3 次、口腔溃疡阳性家族史、有慢性胃病史比例均高于对照组(P<0.05).回归分析显示,血清铁蛋白、维生素 B12、叶酸缺乏、高度工作压力及口腔溃疡家族史是 ROU 发生的独立危险因素(P<0.05).结论:内蒙古呼和浩特地区 ROU 患者存在以铁蛋白、维生素 B12 及叶酸缺乏为核心的多种营养素缺乏,且与高压力状态及阳性家族史密切相关.临床应将血清铁蛋白、维生素 B12 及叶酸水平纳入 ROU 患者的常规检测,实施营养补充与生活方式调整相结合的综合干预策略.
Objective:To explore the distribution characteristics of serum ferritin,vitamin B12 and folic acid levels in patients with recurrent oral ulcer(ROU)in Hohhot,Inner Mongolia and analyze their relationships with disease occur-rence.Methods:From July 2024 to July 2025,60 patients with mild ROU who were admitted to the Affiliated Hospital of In-ner Mongolia Medical University were enrolled as ROU group,and 60 healthy individuals undergoing physical examination were included in control group.Serum ferritin,vitamin B12,folic acid and related hematological indicators were detected in the two groups,and the demographic characteristics,living habits and family history were collected.The independent risk fac-tors for ROU occurrence were analyzed by Logistic regression analysis.Results:The levels of serum ferritin,vitamin B12 and folic acid in ROU group were all lower than those in control group(P<0.05).Serum ferritin,vitamin B12 and folic acid defi-ciency rate were higher in ROU group than those in control group(P<0.05).The proportions of patients with high work-relat-ed stress,preference for spicy foods,irregular meals,less than 3 times of physical exercise per week,positive family history of oral ulcers and history of chronic gastritis in ROU group were all higher compared to control group(P<0.05).Regression a-nalysis revealed that serum ferritin deficiency,vitamin B12 deficiency,folic acid deficiency,high work-related stress and fami-ly history of oral ulcers were independent risk factors influencing the occurrence of ROU(P<0.05).Conclusion:ROU pa-tients in Hohhot,Inner Mongolia suffer from multiple nutrient deficiencies,with ferritin,vitamin B12 and folic acid deficien-cies as the core,which is closely associated with high stress status and positive family history.Clinically,serum ferritin,vita-min B12 and folic acid levels should be included in the routine detection of ROU patients,and a comprehensive intervention strategy combining nutritional supplementation and lifestyle adjustment should be implemented.
王文晔;李丽洁;田亚敏
内蒙古医科大学口腔医学院 内蒙古 呼和浩特 010000内蒙古医科大学附属医院口腔科 内蒙古 呼和浩特 010000内蒙古医科大学附属医院口腔科 内蒙古 呼和浩特 010000
医药卫生
复发性口腔溃疡血清铁蛋白维生素B12叶酸营养缺乏
Recurrent oral ulcerSerum ferritinVitamin B12Folic acidNutrition deficiency
《临床口腔医学杂志》 2026 (8)
484-488,5
评论