童年饥荒暴露与中老年肌少症的关联研究OA

Objective To investigate the association between childhood famine exposure and sarcopenia in middle-aged and elderly individuals.Methods Based on the baseline data in 2011 and follow-up data in 2015 from the China Health and Retirement Longitudinal Study(CHARLS),participants were divided into non-exposed group,fetal exposure group,preschool exposure group,and school-age exposure group according to date of birth,which served as a surrogate indicator of famine exposure.Sarcopenia and its components,including low muscle mass,low muscle strength,and poor physical function,were defined in accordance with the 2019 consensus of the Asian Working Group for Sarcopenia.Multivariate Logistic regression models were adopted to analyze the relationships of famine exposure at different childhood stages with the prevalence and incidence of sarcopenia as well as its components.Results A total of 6 988 participants were enrolled in the baseline analysis.The prevalence of sarcopenia increased gradually across the exposure groups,being 2.41%,3.72%,6.60%,and 10.12%,respectively.After adjusting for confounding factors,famine exposure in preschool and school-age were risk factors for sarcopenia prevalence(OR=3.38,95%CI:2.16 to 5.28;OR=5.65,95%CI:3.65 to 8.74),and also increased the risks of low muscle strength,poor physical function,and low muscle mass.In the follow-up analysis involving 4 781 subjects,preschool and school-age famine exposure elevated the risk of incident sarcopenia to 5.99-fold(95%CI:1.81 to 19.89)and 9.84-fold(95%CI:3.02 to 32.09)respectively,and raised the onset risks of developing all sarcopenia components.Conclusion Famine exposure during preschool and school-age periods significantly increases the risk of sarcopenia in middle-aged and elderly individuals.Early nutritional intervention in childhood should be emphasized.