不同寄主来源的蜜蜂残翅病毒前导蛋白生物信息学分析OA

The leader protein of Deformed wing virus(DWV)was systematically investigated through integrative bioinformatics analysis using complete genome sequences from six phylogenetically diverse hosts of Apis mellifera,Medauroidea extradentata,Varroa destructor,Bougainvillea spectabilis Willdenow,Wisteria sinensis Sweet,and Jasminum nudiflorum Lindley.Despite high overall structural conservation,the leader protein exhibited distinct host-associated sequence variations that reshape predicted phosphorylation and glycosylation landscapes,as well as epitope profiles.These variations were predicted to alter post-translational regulation,subcellular targeting,and host-virus interface dynamics.Collectively,our results identified the DWV leader protein as a conserved yet functionally plastic determinant of viral adaptation,providing mechanistic insight into cross-species transmission.This work established a molecular framework for understanding host-specific viral evolution and highlights the leader protein as a promising target for antiviral intervention.