高原地区急性肺血栓栓塞症诊断与治疗专家共识OA

Extreme natural environments in high-altitude regions can significantly increase the risk of acute pulmonary thromboembolism(PTE).Clinical manifestations of acute PTE in these regions often overlap with those of conditions such as high-altitude pulmonary edema and pneumonia.Moreover,common biomarkers including D-dimer exhibit reduced specificity due to high-altitude physiological adaptation,while clinical assessment tools validated for low-altitude populations may not be applicable here.Coupled with relatively limited medical resources,these factors lead to diagnostic difficulties and inaccurate risk stratification.Although the standard management principles for pulmonary embolism are generally followed,special problems exist,such as increased bleeding risk associated with thrombolysis in hypoxic high-altitude environments and delayed patient transfer.Therefore,the diagnosis,differential diagnosis,and treatment of this disease in high-altitude regions face severe challenges.To address these issues,the Military Clinical Key Specialty(High-Altitude Medicine),Ministry of Education Key Laboratory of Extreme Environmental Medicine,Key Laboratory of Military Logistics Scientific Research,Military Key Laboratory of High-Altitude and Cold Environment Medical Support,and the Army Trauma and Cardiovascular Disease Specialist Alliance took the lead in convening experts nationwide from fields including high-altitude medicine,cardiology,vascular surgery,emergency medicine,critical care medicine,and respiratory and critical care medicine to jointly develop the"Expert consensus on diagnosis and treatment of acute pulmonary thromboembolism in high-altitude regions".This consensus covers four sections on acute PTE in high-altitude regions:epidemiology and pathogenesis,diagnosis,treatment,as well as prevention and follow-up,with a total of 16 recommendations.It puts forward specific suggestions on risk stratification,individualized treatment,prevention strategies,and long-term follow-up,aims to guide the prevention,treatment,and research of acute PTE under special high-altitude environments.