血小板指数与皮肤恶性黑色素瘤的相关性研究OA

Objective:To investigate the association between genetically determined platelet index and cutaneous malignant melanoma(CMM).Methods:Genetic data of platelet count(PLT),mean platelet volume(MPV),platelet distribution width(PDW),and thrombocytopenia(PCT)from the UK Biobank Database and genetic data of CMM from the FinnGen Database were extracted from Genome-wide association studies(GWAS).Inverse variance weighting(IVW),MR-Egger regression,weighted median and weighted pattern methods were used for Mendelian randomization analysis,and sensitivity analysis was per-formed as well.The effect of platelets on the phenotype of A375 cells was studied in vitro.Results:The IVW analysis of PLT for CMM was OR=1.814,95%CI(1.027,3.203),P=0.040;The IVW analysis of MPV for CMM was OR=0.617,95%CI(0.403,0.945),P=0.026;The IVW analysis of PDW was OR=1.148,95%CI(0.674,1.958),P=0.611;The IVW analysis of PCT was OR=1.238,95%CI(0.727,2.110),P=0.432.In vitro experiments confirmed that platelets could promote the pro-liferation of A375.Conclusion:The increase of platelet count and the decrease of mean platelet volume may be the risk factors for CMM.Increased platelets promote A375 cells proliferation in vitro.