阳心方治疗阳虚水泛型心力衰竭合并焦虑抑郁状态的临床疗效观察OA

Objective To observe the clinical efficacy of Yangxin Formula(composed of Angelicae Sinensis Radix,Poria,Ginseng Radix et Rhizoma Rubra,Xinhui Citri Reticulatae Pericarpium,Dendrobium fimbriatum)in patients with heart failure(HF)of yang deficiency and water flooding syndrome complicated by anxiety and depression.Methods A total of 60 patients with HF of yang deficiency and water flooding syndrome complicated by anxiety and depression,who received treatment in the outpatient or inpatient department of Cardiology,Dade Road General Hospital,Guangdong Provincial Hospital of Chinese Medicine from August 2024 to January 2025,were enrolled and randomly divided into an observation group and a control group using a random number table,with 30 patients in each group.Both groups received standardized western medical treatment for HF,while the observation group additionally received Yangxin Formula.The treatment duration was 24 weeks.The two groups were compared in terms of traditional Chinese medicine(TCM)syndrome score,Self-rating Depression Scale(SDS)score,Self-rating Anxiety Scale(SAS)score,Minnesota Living with Heart Failure Questionnaire(MLHFQ)score,New York Heart Association(NYHA)functional class,as well as plasma N-terminal pro-brain natriuretic peptide(NT-proBNP)and soluble suppression of tumorigenicity 2(ST2)levels,and left ventricular ejection fraction(LVEF)after 1,3,and 6 months of treatment.Results(1)For TCM syndrome efficacy,after 1 month of treatment,the total effective rate was 36.67%(11/30)in the observation group and 13.00%(4/30)in the control group;after 3 months,the rates were 76.67%(23/30)vs.46.67%(14/30);after 6 months,the rates were 93.33%(28/30)vs.66.67%(20/30).The observation group showed significantly better TCM syndrome efficacy than the control group at all time points,the difference being statistically significant(P＜0.05 or P＜0.01).(2)For improvement of anxiety and depression,no significant differences were found between the two groups in SAS and SDS scores after 1 or 3 months(P＞0.05);however,after 6 months,the observation group showed significantly greater improvement in both SAS and SDS scores than the control group,the difference being statistically significant(P＜0.05 or P＜0.01).(3)For quality of life,no significant differences in MLHFQ scores were observed after 1 or 3 months(P＞0.05);after 6 months,the observation group exhibited significantly greater improvement in MLHFQ score than the control group,the difference being statistically significant(P＜0.05).(4)For HF parameters,no significant differences were found between the two groups in NYHA functional class,plasma NT-proBNP and ST2 levels,or LVEF after 1,3,or 6 months(P＞0.05).Conclusion Adding Yangxin Formula to conventional western medicine yields superior clinical efficacy compared with conventional western medicine alone in treating HF with yang deficiency and water flooding syndrome complicated by anxiety and depression,effectively improving TCM symptoms,anxiety,depression,and quality of life.However,largescale,multicenter randomized controlled trials are needed to further investigate the effects of Yangxin Formula on objective HF parameters.