自制固相微萃取探针结合小型便携式质谱仪现场快速分析奶瓶洗液中6种酚类内分泌干扰物OA

In this study,an on-site rapid detection method for 6 kinds of phenolic endocrine disruptors in baby bottle cleaning solution was established using solid-phase microextraction(SPME)coupled with nano-electrospray ionization and a miniature mass spectrometer.The polyacrylonitrile/multi-walled carbon nanotube(PAN/MWCNTs)coating of SPME probe was prepared by electrospinning.Using a stainless steel needle as the base material of the SPME probe,the coating of the PAN fibers and MWCNTs were successively modified on the surface of the steel needle and the microscopic structure indicated that the probe coating was a network-like three-dimensional porous structure.The probe was applied to extraction and enrichment of 6 kinds of phenolic endocrine disruptors,including bisphenol A and 4-tert-butylphenol,in baby bottle cleaning solution.The extraction temperature was set at 45℃with a stirring speed of 400 r/min and an extraction time of 3 min.After extraction,the probe was inserted into a borosilicate glass capillary containing 10 μL acetonitrile,and the ionization voltage was applied.The target substances were immediately analyzed by the miniature mass spectrometer.The limits of detection(LOD)and limits of quantification(LOQ)for the six kinds of endocrine disruptors were 10-20 ng/mL and 20-50 ng/mL,respectively.The recoveries were between 87.8%and 106.9%with the relative standard deviations(RSDs)from 4.4%to 11.2%,and the matrix effect was between 0.95 and 1.02.The streamlined analytical workflow was done within 5 min.The custom-made SPME probe had strong stability and high extraction efficiency.The developed method was simple,rapid,accurate and suitable for on-site rapid analysis of phenolic endocrine disruptors in baby bottle cleaning solutions.