季节性过敏性鼻炎患者花粉暴露状态下鼻分泌物嗜酸性粒细胞定量特征及临床意义OA

OBJECTIVE To compare eosinophilic inflammation in nasal secretions between patients with seasonal allergic rhinitis(SAR)examined during and outside the pollen season,and to assess the associations between eosinophil-related parameters and symptom severity.METHODS A total of 162 patients with SAR who attended Beijing Tongren Hospital between December 2023 and January 2025 were enrolled and divided into pollen-season and non-pollen-season groups according to whether their visit occurred during the pollen season.Nasal secretion smears were evaluated using quantitative cell counting and semiquantitative grading.Associations between eosinophil(Eos)-related parameters and symptom scores were analyzed.RESULTS The pollen-season group included 97 patients,and the non-pollen-season group included 65 patients.Nasal symptom scores,medication scores,peripheral blood Eos percentage and count,as well as nasal secretion Eos percentage,Eos count,proportion of degranulated Eos,and degranulated Eos count were all significantly higher in the pollen-season group.No significant difference was observed in semiquantitative Eos grading between the two groups.Nasal secretion Eos percentage and the proportion of degranulated Eos were positively correlated with multiple nasal symptom scores.CONCLUSION Systemic and local eosinophilic inflammation was increased in patients with SAR during the pollen season.Quantitative assessment of nasal Eos,particularly evaluation of Eos degranulation,may provide an objective reference for assessing inflammation severity and disease activity.