基于"菌群-代谢-免疫"轴从"浊毒"论治腹泻型肠易激综合征OA

The pathogenesis of diarrhea-predominant irritable bowel syndrome(IBS-D)has not yet been fully elucidated.Its development and progression are closely related to intestinal flora imbalance,metabolic dysregulation,and immune dysfunction,resulting from the interactive interplay of microbiota,metabolism,and immunity.Traditional Chinese Medicine(TCM)posits that the key pathogenesis of IBS-D lies in liver-spleen disharmony.Li Diangui proposes the"Turbid Toxin Theory,"suggesting that liver stagnation-spleen deficiency and internal accumulation of turbid toxins constitute the primary pathogenesis of IBS-D.Based on the"gut microbiota-metabolism-immunity"axis and starting from the turbid-toxin theory,this study explores the correlation between the two.Gut microbiota dysbiosis shares physiological similarities with spleen deficiency.The metabolic disorders and activated immune-inflammatory responses caused by gut microbiota dysbiosis align with the pathogenic characteristics of turbid toxin.Regulating the"gut microbiota-metabolism-immunity"axis by soothing the liver,strengthening the spleen,resolving turbidity,and detoxifying has certain value in treating IBS-D.