基于"脑-肠轴"探讨"运土疏木"理论治疗糖尿病共病抑郁症机制OA

Based on the pathogenesis of"earth stagnation leading to wood depression",this study proposes the application of the"transporting earth and dredging wood"method for treating diabetes-depression comorbidity,exploring its intrinsic connection with the regulation of the"gut-brain axis".The pathogenesis of"earth stagnation leading to wood depression"in diabetes-depression comorbidity aligns with the modern medical mechanism of"gut dysbiosis leading to intestinal barrier damage,triggering chronic inflammation,which then induces depression and exacerbates metabolic disorders via the gut-brain axis."The key treatment involves"transporting earth"(strengthening the spleen and resolving dampness)to regulate gut microbiota and reduce inflammatory responses,combined with"dredging wood"(soothing the liver and promoting qi flow)to modulate mood and neuroendocrine function,thereby improving clinical symptoms of diabetes-depression comorbidity.Through mutual verification of Chinese and Western medical theories,this study reveals the scientific connotation of the"transporting earth and dredging wood"method in treating diabetes-depression comorbidity,providing systematic theoretical support for establishing"brain-gut axis"interventions.