复杂食品基质中污染物的纸基微流控检测进展OA

To address the challenges of complex matrices,fragmented detection workflows,and insufficient standardized validation in the on-site rapid screening of food contaminants,this review systematically summarizes the research progress of paper-based microfluidic platforms for food contaminant detection.Recent studies are categorized and analyzed from four perspectives:paper-based materials and structural configurations,signal transduction and readout strategies,typical contaminant detection applications,and bottlenecks in practical deployment.Existing research has developed diverse substrate materials including cellulose filter paper,nitrocellulose membranes,glass fiber paper,office paper,nanocellulose paper,and composite functional paper.Multiple detection modalities have been established,including colorimetric,fluorescent,chemiluminescent,electrochemical,surface-enhanced Raman scattering,photoelectrochemical,and smartphone-assisted readout.Representative studies have achieved on-site pesticide detection within 10 minutes and simultaneous detection of four heavy metals,with recoveries ranging from 84.0%to 104.1%in real samples.However,the limits of detection,recoveries,reproducibility,and on-site quantitative capabilities of paper-based microfluidic platforms vary considerably across different contaminant categories,food matrices,and signal readout modes.Although paper-based microfluidic platforms offer advantages such as low cost,portability,and ease of integration,their application remains constrained by matrix interference from complex food samples,insufficient device batch-to-batch consistency,limited pretreatment capability,and insufficient standardized validation.Future efforts should focus on modular pretreatment,multimodal signal validation,standardized smartphone-based readout,and validation with real samples.