Expression characteristics of serum exosomal microRNAs in patients with liver injury induced by anti‑tuberculosis drugsOA
In China,drug‑induced liver injury(DILI)caused by anti‑tuberculosis drugs is a serious problem that can lead to acute liver failure and even death in severe cases.In particular,when first‑line anti‑tuberculosis drugs such as isoniazid and rifampicin are used,the risk of liver injury significantly increases,which not only affects the quality of life of patients but also may lead to treatment interruption,changes in treatment plans,and the development of drug resistance[1].Therefore,early identification and specific recognition of antituberculosis drug‑induced liver injury(ATB‑DILI/TB‑DILI)to avoid serious liver injury or even liver failure and early intervention have significant clinical importance.
Yinpeng Jin;Xiaofang Yu;Mingquan Guo;Li Li;Shuangshuang Sun;Liling Yang;Ying Yuan;Qingchun Fu;Rongfeng Shi;Meng Jin
Clinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaClinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaDepartment of Laboratory Medicine,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaClinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaClinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaClinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaClinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaClinical Research Center for Liver Diseases,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaDepartment of Interventional&Vascular Surgery,Affiliated Hospital of Nantong University,Nantong 226001,China Institute of Interventional and Vascular Therapy,Affiliated Hospital of Nantong University,Nantong 226001,ChinaSchool of Medical Devices,Shanghai Health Medical College,Shanghai 200120,China
医药卫生
liver injury dili causedSerum exosomal microRNAsDrug induced liver injuryliver injuryacute liver failureidentification spedrug resistance thereforeearlyAnti tuberculosis drugs
《Acta Biochimica et Biophysica Sinica》 2026 (5)
P.1183-1186,4
supported by the grants from the Three‑year Action Plan for Strengthening the Construction of the Public Health System in Shanghai(No.GWVI‑11.2‑YQ01)the Project of Shanghai Public Health Clinical Center(No.KY‑GW‑2020‑14).
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